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Case Report
Sonidegib: Real-life experience with Hedgehog inhibitor for the treatment of locally advanced basal cell carcinoma
1 Unità Operativa Complessa Oncologia, Ospedale “S. Vincenzo”, Taormina (ME), Sicily, Italy
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Alessia Dottore
Alessia Dottore, Unità Operativa Complessa Oncologia, Ospedale “S. Vincenzo”, Taormina (ME), Sicily,
Italy
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Article ID: 100134Z10AD2024
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Dottore A, Briguglio R, Priolo D, Ferraù F. Sonidegib: Real-life experience with Hedgehog inhibitor for the treatment of locally advanced basal cell carcinoma. J Case Rep Images Oncology 2024;10(2):6–9.ABSTRACT
Introduction: Sonidegib, a Hedgehog inhibitor approved for the treatment of advanced basal cell carcinoma (BCC), reported an objective response rate of 60.6% (central review) and 74.2% (investigator review) and a median duration of response of 26.1 months in the pivotal trial BOLT. The therapy showed an excellent tolerability profile. The most frequent adverse events are muscle spasms, dysgeusia, alopecia, nausea, increased creatine kinase, weight loss and fatigue.
Case Report: This article reports the case of a neglected patient in which sonidegib rapidly led to an important tumor mass reduction and improvement of quality of life without of adverse effects.
Conclusion: The peculiar efficacy and tolerability of sonidegib, in addition to representing a current gold standard for the treatment of the advanced disease, allow us to hypothesize its use on a larger scale in a modern multidisciplinary strategy (delete with surgery and radiotherapy).
Keywords: Basal cell carcinoma, Real-life experience, Sonidegib
SUPPORTING INFORMATION
Author Contributions
Alessia Dottore - Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Roberta Briguglio - Acquisition of data, Drafting the article, Final approval of the version to be published
Domenico Priolo - Acquisition of data, Drafting the article, Final approval of the version to be published
Francesco Ferraù - Substantial contributions to conception and design, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Alessia Dottore et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
