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Case Report
Oral melanotic hyperpigmentation following external beam radiotherapy for mucoepidermoid carcinoma of the parotid gland
1 University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
2 University of Tennessee Medical Center, Knoxville, TN, USA
3 Bismarck Cancer Center, Bismarck, ND, USA
Address correspondence to:
John M Watkins
MD, Bismarck Cancer Center, 500 N 8th Street, Bismarck, ND 58501,
USA
Message to Corresponding Author
Article ID: 100131Z10JK2024
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Kaelberer JB, Rummel KA, Watkins JM. Oral melanotic hyperpigmentation following external beam radiotherapy for mucoepidermoid carcinoma of the parotid gland. J Case Rep Images Oncology 2024;10(1):24–26.ABSTRACT
Introduction: Epithelial hyperpigmentation from is a commonly encountered side effect from radiation therapy applications, most frequently described in skin. We here report a case of radiotherapy-associated oral hyperpigmentation.
Case Report: A 46-year-old female with parotid mucoepidermoid carcinoma underwent resection with involved margins, followed by adjuvant radiotherapy. During her course of treatment, non-tender, non-confluent, well-demarcated palatal and lingual hyperpigmented macules were noted, monitored without intervention. Serial images demonstrate gradual resolution during several months post-treatment.
Conclusion: Oral hyperpigmentation is likely an underreported phenomenon, and appears to be largely cosmetic, with stigmata resolving gradually over time.
Keywords: Hyperpigmentation, Oral cavity, Radiotherapy
SUPPORTING INFORMATION
Author Contributions
Joshua B Kaelberer - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Final approval of the version to be published
Keaton A Rummel - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
John M Watkins - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Joshua B Kaelberer et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
