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Case Report
Adjuvant chemotherapy and radiation therapy in the first trimester of a pregnant woman with breast cancer: A case report
1 Division of Oncology and Hematology, Department of Internal Medicine, Konyang University Hospital, 158, Gwanjeo-dong-ro, Seo-gu, Daejeon, Korea
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Do Yeun Cho
Associate Professor at Division of Hematology and Oncology, Department of Internal Medicine, Konyang University Hospital, 158, Gwanjeo- dong-ro, Seo-gu, Daejeon 302-718,
Korea
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Article ID: 100058Z10JC2018
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Choi JG, Baek SW, Jang TS, Cho DY. Adjuvant chemotherapy and radiation therapy in the first trimester of a pregnant woman with breast cancer: A case report. J Case Rep Images Oncology 2018;4:100058Z10JC2018.ABSTRACT
Introduction: Breast cancer is the second most common malignancy in pregnant women. Overall, the possibility of breast cancer during pregnancy is increasing due to a trend for women to delay childbearing. Despite the growing number of women with breast cancer during pregnancy, few case reports describe chemotherapy during pregnancy. Chemotherapy during the first trimester increases the risk of spontaneous abortion, fetal death, and major malformations with birth defects. However, the risk of chemotherapy for the fetus seems relatively low when administered in the second and third trimesters of pregnancy.
Case Report: We report a case of a pregnant patient with breast cancer who was treated with adjuvant chemotherapy followed by radiation therapy during the first trimester and delivered a baby without fetal malformations or growth retardation. The 34-year-old woman with stage IIA breast cancer received adjuvant chemotherapy and radiation therapy after undergoing lumpectomy and lymph node dissection. The pregnancy was incidentally diagnosed during a postoperative computed tomography (CT) scan conducted 32 weeks after surgery. Obstetric examination revealed a gestational age of 29 weeks and no findings of specific deformations. Following consultation with our multidisciplinary team and in consideration of the needs of the patient, her family, and the condition of the fetus, the pregnancy was not terminated. The patient gave birth to a healthy baby at 36 weeks of pregnancy.
Conclusion: This case serves as a reminder that birth can be considered even if chemotherapy is administered during the first trimester of pregnancy.
Keywords: Breast cancer, Chemotherapy, Pregnancy, Radiation therapy
SUPPORTING INFORMATION
Author Contributions
Jong Gwon Choi - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Seung Woo Baek - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Tae Soo Jang - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Do Yeun Cho - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this case report.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2018 Jong Gwon Choi et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
