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Case Report
A case of disseminating central neurocytoma increased methionine uptake
1 MD, Director, Department of Neurosurgery, Hokuto Hospital, Obihiro, Hokkaido, Japan
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Akira Tempaku
7-5 Inada-cho-kisen, Obihiro, Hokkaido 080-0833,
Japan
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Article ID: 100147Z10AT2025
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Tempaku A. A case of disseminating central neurocytoma increased methionine uptake. J Case Rep Images Oncology 2025;11(2):1–5.ABSTRACT
Introduction: Central neurocytoma is one of the benign central nervous system neoplasms, typically identified through imaging studies of the head, without any neurological deficits. However, occasional growth or dissemination may cause central nervous system disorders due to hydrocephalus. Radiographical findings can sometimes make it difficult to detect increased lesions.
Case Report: A 56-year-old man presented with hydrocephalus. This was caused by expansion of the central neurocytoma, which was caused by intratumoral hemorrhage. The tumor was diagnosed through pathological analysis after a biopsy and third ventriculostomy. Half a year after the diagnostic surgery, he experienced a recurrence of hydrocephalus. This was accompanied by cognitive dysfunction. Positron emission tomography (PET) with 11C-methionine uptake showed disseminated neoplastic lesions surrounding the ventricle walls.
Conclusion: The methionine PET study revealed a rare case of central neurocytoma. Cases of this tumor that have disseminated or transformed exhibit increased cell viability, including protein synthesis. These changes result in increased methionine accumulation in tumor lesions.
Keywords: Central neurocytoma, Dissemination, Methionine, PET
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Acknowledgments
The author thanks medical staff of Hokuto Hospital to support clinical treatment and care for the patient.
Author ContributionsAkira Tempaku - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthor declares no conflict of interest.
Copyright© 2025 Akira Tempaku. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
