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Case Report
A rare case of pancreatic mixed acinar-neuroendocrine carcinoma
1 Hospitalist, Internal Medicine, ThedaCare Regional Medical Center, Appleton, Wisconsin, USA
2 Hematologist and Oncologist, Cumberland Medical Center, Crossville, Tennessee, USA
Address correspondence to:
Faraz A
TN,
USA
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Article ID: 100138Z10ZK2024
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Zhou K, Faraz A, Hendrixson M. A rare case of pancreatic mixed acinar-neuroendocrine carcinoma. J Case Rep Images Oncology 2024;10(2):26–30.ABSTRACT
Pancreatic mixed acinar-neuroendocrine carcinoma (pMANEC) is an extremely rare malignancy with both acinar carcinomas with neuroendocrine lineage differentiations. Herein, we present a case of pMANEC in a 78-year-old male who initially presented to the clinic for night sweats, easy bruising, and lumbar pain, leading to the discovery of a pancreatic mass on imaging. Pathological examinations, including immunohistochemistry, confirmed the diagnosis of possible pMANEC, characterized by acinar and neuroendocrine differentiation. Further diagnostic workup with DOTATATE NM positron emission tomography/computed tomography (PET/CT) scan provided additional insights, confirming the neuroendocrine nature of the tumor. The patient was started on gemcitabine and nab-paclitaxel every other week and also started on lanreotide for treatment. Our case highlights the challenges in diagnosing and managing this rare entity and underscores the need for further research to explore its clinical behavior, molecular characteristics, and optimal therapeutic strategies. Additionally, the potential role of genetic profiling and immunotherapy in improving outcomes for patients with pMANEC warrants investigation.
Keywords: Acinar cancer, Cancer, Mixed acinar neuroendocrine cancer, Neuroendocrine cancer, Pancreas, Pancreatic cancer
SUPPORTING INFORMATION
Author Contributions
Zhou K - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Faraz A - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hendrixson M - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Zhou K et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
