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Case Report
A case of triple hit lymphoma and rapid deterioration
1 Department of Internal Medicine, St. Luke’s University Hospital, Bethlehem, PA 18015, USA
2 Department of Medical Oncology, St. Luke’s University Hospital, Bethlehem, PA 18015, USA
Address correspondence to:
Jasmit Walia
DO, St. Luke’s University Hospital, 801 Ostrum Street, Bethlehem, PA 18015,
USA
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Article ID: 100118Z10JW2023
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Walia J, Daly T, Tahir A, Wilson M, Bhagatwala K. A case of triple hit lymphoma and rapid deterioration. J Case Rep Images Oncology 2023;9(1):8–11.ABSTRACT
Triple hit lymphomas (THL) comprise a rare, heterogenous group of lymphomas and like many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. Traditionally referred to as a subset of double hit lymphomas (DHL) in literature, THLs characteristically involve chromosomal rearrangements of c-MYC, BCL-2, and BCL-6 oncogenes. Many case series of high-grade B-cell lymphoma, especially MYC/BCL2 double hit lymphoma, have been described in the literature, but relatively few cases of triple hit lymphoma have been reported. Additionally, without chemotherapy, triple hit lymphomas are known to have a rapid clinical course and poor prognosis compared to double hit lymphomas. Here we present a case of MYC/BCL2/BCL6 triple hit lymphoma in a patient previously diagnosed with marginal B-cell lymphoma at stage IIA after biopsy of intra-abdominal lymph nodes status post one treatment with rituximab and bendamustine. Unfortunately, this patient had a rapid decline and presumed central nervous system (CNS) infiltration and passed away within 30 days of diagnosis.
Keywords: B-cell lymphoma, Lymphoma, Oncogenes
SUPPORTING INFORMATION
Author Contributions
Jasmit Walia - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Timothy Daly - Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ali Tahir - Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Melissa Wilson - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Kunal Bhagatwala - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2023 Jasmit Walia et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
