Case Report


A case of delayed primary-CNS post-transplant lymphoproliferative disorder in a patient with concurrent metastatic colorectal malignancy

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1 Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

2 Department of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

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Vinay Ayyappan

3400 Spruce St., Philadelphia, PA 19104,

USA

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Article ID: 100115Z10VA2022

doi: 10.5348/100115Z10VA2022CR

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How to cite this article

Ayyappan V, Smith N, Tian Y, Miller J. A case of delayed primary-CNS post-transplant lymphoproliferative disorder in a patient with concurrent metastatic colorectal malignancy. J Case Rep Images Oncology 2022;8(2):45–49.

ABSTRACT


Introduction: Post-transplant lymphoproliferative disorders (PTLD) are a complication of immunosuppression following organ transplantation. Due to their heterogeneous presentation, diagnosis of PTLD can be challenging.

Case Report: In this case report, we present a patient with metastatic colon cancer, with remote history of multivisceral organ transplant 20-years prior, who presented with altered mental status and was diagnosed with primary central nervous system PTLD.

Conclusion: This case illustrates the importance of continued suspicion of PTLD long after transplantation in solid-organ transplant recipients, even in the setting of multiple comorbidities.

Keywords: Immunosuppression, Lymphoproliferative disorders, Neoplasms, Organ transplantation

SUPPORTING INFORMATION


Acknowledgments

V.A. acknowledges support from NIH Medical Scientist Training Program 5T32GM007170.

Author Contributions

Vinay Ayyappan - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Nichole Smith - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Final approval of the version to be published

Ye Tian - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Jean Miller - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Guaranter of Submission

The corresponding author is the guarantor of submission.

Source of Support

None

Consent Statement

Written informed consent was obtained from the patient for publication of this article.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Conflict of Interest

Authors declare no conflict of interest.

Copyright

© 2022 Vinay Ayyappan et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.