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Case Report
Severe hyponatremia in the setting of mediastinal neuroblastoma in an elderly male
1 Florida International University, Herbert Wertheim College of Medicine, 11200 SW Eighth St, Unit AHC2, Miami, FL 33199, United States
2 Baptist Health Medical Group, 6200 SW 73 Street, Miami, FL 33143, United States
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Alexander Black
Florida International University, Herbert Wertheim College of Medicine, 11200 SW Eighth St, Unit AHC2, Miami, FL 33199,
United States
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Article ID: 100110Z10AB2022
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Black A, Gohel N, Kanikireddy S. Severe hyponatremia in the setting of mediastinal neuroblastoma in an elderly male. J Case Rep Images Oncology 2022;8(2):15–19.ABSTRACT
Introduction: Neuroblastomas are rare neoplasms with the potential to express paraneoplastic syndromes.
Case Report: We report the case of a 77-year-old male with biopsy-confirmed unresectable anterior mediastinal neuroblastoma with symptomatic hyponatremia likely due to paraneoplastic syndrome of inappropriate antidiuretic hormone (SIADH). He had multiple inpatient admissions for symptomatic hyponatremia over the 3-year period that we examined, with a paucity of admissions during chemoreduction with adjuvant radiation therapy. Due to the rarity of this tumor, there is no standard treatment protocol and the literature regarding these neoplasms exists primarily as case reports.
Conclusion: This case report adds to the existing literature detailing paraneoplastic SIADH in the setting of mediastinal neuroblastoma in adults and highlights the importance for oncologists to be cognizant of this syndrome as a complication of a particular rare malignancy.
Keywords: Hyponatremia, Neuroblastoma, Oncology, Paraneoplastic syndrome
SUPPORTING INFORMATION
Author Contributions
Alexander Black - Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Nishant Gohel - Acquisition of data, Drafting the article, Final approval of the version to be published
Sankarabharan Kanikireddy - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Alexander Black et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
