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Case Report
Abdominal aortitis with immune checkpoint inhibition
1 Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
2 Lifespan Cancer Institute, Rhode Island Hospital, Providence, RI, USA
3 Warren Alpert School of Medicine, Brown University, Providence, RI, USA
Address correspondence to:
Nicholas R Liguori
Lewis Katz School of Medicine, Temple University, Philadelphia, PA,
USA
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Article ID: 100092Z10NL2021
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Liguori NR, Longo MV, Safran H. Abdominal aortitis with immune checkpoint inhibition. J Case Rep Images Oncology 2021;7:100092Z10NL2021.ABSTRACT
Introduction: Aortitis, inflammation of the aorta, is a rare large vessel vasculitis associated with giant cell arteritis, Takayasu arteritis, and other rheumatologic diseases. Aortitis has rarely been reported with cancer immunotherapy.
Case Report: We present a case of 43-year-old man treated for a high-grade neuroendocrine tumor who developed aortitis during treatment with the PD-L1 inhibitor atezolizumab. PubMed search revealed no prior cases of this toxicity in associated with PD-L1 inhibition.
Conclusion: To our knowledge this is the first case report of aortitis from PD-L1 inhibition. Recognition is important since resolution of symptoms was obtained with corticosteroids. This is also the first report of successful rechallenge with a PD-1 inhibitor without recurrence of aortitis.
Keywords: Aortitis, Atezolizumab, PD-1 inhibitor, PDL1 inhibitor
SUPPORTING INFORMATION
Author Contributions
Nicholas R Liguori - Substantial contributions to conception and design, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Michael V Longo - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Howard Safran - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestThe authors declare that the case report production was conducted in the absence of any commercial or financial relationships that would classify as a conflict of interest.
Copyright© 2021 Nicholas R Liguori et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
