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Case Report
A rare case report of extra medullary plasmacytoma involving the posterior mediastinum coexistent with multiple myeloma
1 PGY2 Resident, MD, Department of Internal Medicine, The Brooklyn Hospital, Center Clinical Affiliate of Mount Sinai Hospital, 121 Dekalb Avenue, Brooklyn, NY, USA
2 Fellow in Hematology and Oncology, Department of Hematology and Oncology, The Brooklyn Hospital Center clinical affiliate of Mount Sinai Hospital, 121 Dekalb Avenue, Brooklyn, NY, USA
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Lohitha Dhulipalla
PGY2 Resident, MD, Department of Internal Medicine, The Brooklyn Hospital, Center Clinical Affiliate of Mount Sinai Hospital, 121 Dekalb Avenue, Brooklyn, NY 11201,
USA
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Article ID: 100088Z10LD2021
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Dhulipalla L, Karki M, Huq A, Rana A. A rare case report of extra medullary plasmacytoma involving the posterior mediastinum coexistent with multiple myeloma. J Case Rep Images Oncology 2021;7:100088Z10LD2021.ABSTRACT
Introduction: Plasma cell neoplasms are characterized by the clonal proliferation of plasma cells. They include monoclonal gammopathy of undetermined significance, multiple myeloma, and solitary osseous or non-osseous plasmacytoma. Multiple myeloma is characterized by the proliferation of plasma cells in the bone marrow and can result in extensive skeletal destruction, whereas plasmacytoma is characterized by the proliferation of plasma cells restricted to one area of the body.
Case Report: A 65-year-old female presented for workup of incidental mass noted on computed tomography (CT) of the chest. She was noted to have posterior mediastinal plasmacytoma with elevated IgA and free lambda light chains on serum electrophoresis. She subsequently underwent the bone marrow biopsy which revealed multiple myeloma. The patient was diagnosed with IgA lambda multiple myeloma with a posterior mediastinal plasmacytoma with multiple bony lesions. She underwent radiotherapy with interval resolution of posterior mediastinal mass and currently on chemotherapy for multiple myeloma.
Conclusion: Once plasmacytoma is diagnosed, a further workup for multiple myeloma is needed as treatment is entirely different for both types of plasma cell neoplasms.
Keywords: Extramedullary plasmacytoma, Extramedullary plasmacytoma coexistent with multiple myeloma, Medullary plasmacytoma, Multiple myeloma, Plasmacytoma
SUPPORTING INFORMATION
Author Contributions
Lohitha Dhulipalla - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Monika Karki - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Ammar Huq - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Anshuma Rana - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Lohitha Dhulipalla et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
