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Case Report
In vitro fertilization pregnancy following treatment of diffuse malignant peritoneal mesothelioma
1 Resident, Department of Obstetrics and Gynecology, San Antonio Military Medical Center, Fort Sam Houston, Texas, USA
2 Faculty, Department of Reproductive Endocrinology and Infertility, Fertility Center of San Antonio, San Antonio, Texas, USA
3 Faculty, Department of Gastroenterology, San Antonio Military Medical Center, Fort Sam Houston, Texas, USA
4 Faculty, Department of Pathology, Keesler Air Force Base, Biloxi, Mississippi, USA
5 Faculty and Residency Program Director, Department of Reproductive Endocrinology and Infertility, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
Address correspondence to:
Viviana de Assis
DO, CPT, USAF, MC, San Antonio Military Medical Center, Department of Obstetrics and Gynecology, 3551 Roger Brooke Dr., Fort Sam Houston, Texas 78234,
USA
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Article ID: 100043Z08VA2019
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How to cite this article
de Assis V, Adams J, Marowske JH, Cochet A, Walton D, Saunders R. In vitro fertilization pregnancy following treatment of diffuse malignant peritoneal mesothelioma. J Case Rep Images Obstet Gynecol 2019;5:100043Z08VA2019.ABSTRACT
Introduction: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare aggressive neoplasm. Cytoreductive surgery (CRS) and hyperthermic intraoperative peritoneal perfusion chemotherapy (HIPEC) increased overall survivals but the impact on women’s fertility after treatment is unknown.
Case Report: A 28-year-old with primary infertility and recurrent ascites was diagnosed with epithelioid subtype DMPM. Ovarian suppression was achieved with a GnRH-agonist prior to treatment. Two years after remission, she underwent invitro fertilization (IVF) and delivered a healthy female infant at term.
Conclusion: Patients with DMPM have a 50% survival at five years with CRS and HIPEC. We report the rare case of a live birth achieved with IVF following CRS and HIPEC treatment for DMPM. Pre-chemotherapy GnRH treatment offered ovarian suppression while possibly optimizing fertility preservation.
Keywords: Cytoreductive surgery, Diffuse malignant peritoneal mesothelioma, GnRH agonist therapy, Hyperthermic intraoperative peritoneal perfusion chemotherapy, In-vitro fertilization pregnancy
SUPPORTING INFORMATION
Author Contributions
Viviana de Assis - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Jaye Adams - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Johanna Hollweg Marowske - Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Allyson Cochet - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Doug Walton - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Rhiana Saunders - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this case report.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Viviana de Assis et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
