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Case Report
 
Diffuse large B cell lymphoma with central pontine myelinolysis
Sumaira Shafi1, Cristian Papazoglu1, Prasanta Basak2, Stephen Jesmajian3
1Resident, Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore New Rochelle Hospital, New Rochelle, NY, USA.
2Attending Physician, Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore New Rochelle Hospital, New Rochelle, NY, USA.
3Program Director, Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore New Rochelle Hospital, New Rochelle, NY, USA.

Article ID: 100003Z10SS2015
doi:10.5348/Z10-2015-3-CR-3

Address correspondence to:
Sumaira Shafi
16 Guion Place
New Rochelle, NY
USA, 10802
Phone: 1-914-6891659
Fax: 1-914-365- 5489

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How to cite this article:
Shafi S, Papazoglu C, Basak P, Jesmajian S. Diffuse large B cell lymphoma with central pontine myelinolysis. J Case Rep Images Oncology 2015;1:10–14.


Abstract
Introduction: Diffuse large B cell lymphoma is the most common type of non-Hodgkin, lymphoma among adults, with an annual incidence of 7–8 cases per 100, 000 people per year.
Case Report: We report a case of diffuse large B cell lymphoma with isolated splenomegaly, complicated by central pontine myelinolysis. Solitary splenic non-Hodgkin's lymphoma is rare; with an incidence less than 1%. Treatment of diffuse large B cell lymphoma led to the resolution of the pontine lesion. The association of central pontine myelinolysis with diffuse large B cell lymphoma is exceedingly rare, with only one case report published till date.
Conclusion: Diffuse large B cell lymphoma presenting as isolated splenomegaly is rare and can be a diagnostic challenge. The association of central pontine myelinolysis with diffuse large B cell lymphoma is rare and the possibility that central pontine myelinolysis could be an early manifestation of lymphoma or a paraneoplastic syndrome needs to be further explored.

Keywords: Diffuse large B cell lymphoma, Central pontine myelinolysis


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Author Contributions
Sumaira Shafi – Substantial contributions to conception and design, Acquisition of the data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Cristian Papazoglu – Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published.
Prasanta Basak – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Stephen Jesmajian – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
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Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Sumaira Shafi et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.